Why remdesivir works against SARS-CoV-2 but not on other viruses

Understanding drugs and viruses key to being ready for the next pandemic

Why remdesivir works against SARS-CoV-2 but not on other virusesUnderstanding exactly how antiviral drugs interact with viruses at a molecular level will be key to developing the broad-spectrum therapies needed to battle against the SARS-CoV-2 pandemic and get ready to fight the next one, according to a newly published paper in the The Journal of Biological Chemistry. The paper reveals the inner workings of the…

We must address the growing crisis of opioid-related deaths

Drug users are going to keep using, so a better route to saving lives is to ensure drugs are clean and safe

We must address the growing crisis of opioid-related deathsWe’re supposed to be merry and bright as we approach the holidays and the new year. This year, there are many reasons to be less cheerful and festive. We’ve managed to make it through floods, fires and heat domes, but the pandemic persists with the Omicron mutation, inflation threatens our economy and the big, ugly…

Does prescribed opioid use in children lead to later drug misuse?

Calls for rigorous research to determine if short-term medical use in children is safe

Does prescribed opioid use in children lead to later drug misuse?Pediatric researchers are calling for more rigorous research into the possible link between short-term opioid use for pain management in childhood and opioid use disorder later in life. The University of Alberta team reviewed the results of 21 previous studies but found no definitive answer to the question, according to a new study published this week in…

Made-in-Alberta vaccine and drug development pipeline gets funding

Alberta invests $55.1M to taking vaccines, antiviral drugs from discovery to manufacturing

Made-in-Alberta vaccine and drug development pipeline gets fundingAlberta is building a better pipeline, but this one’s not for oil and gas products – it’s for vaccines and therapeutic drugs to fight viral diseases. The province announced a $55.1-million grant on Wednesday for University of Alberta research on ways to prevent and treat COVID-19, including $15 million for vaccine projects and $10 million for studies…

The new drug-price reform not what the doctor ordered

The well-being of patients is at risk

The new drug-price reform not what the doctor orderedBy Krystle Wittevrongel and Maria Lily Shaw Montreal Economic Institute A highly-contested drug-price reform is set to come into effect in Canada in January 2022. Critics of the major overhaul, including patient groups, doctors, and academics, are hopeful that the new federal cabinet will take their concerns to heart and rather than stifle pharmaceutical innovation,…

Promising chemotherapy treatment for bladder cancer enters human trials

A rejected patent application nearly derailed years of research, but support from experts saved the day

Promising chemotherapy treatment for bladder cancer enters human trialsIn 2015, University of Alberta cancer researcher Jack Tuszynski learned that his patent application for a promising chemotherapy treatment for people suffering from metastatic bladder cancer had been rejected by the U.S. Patent Office. “That was it. I thought, ‘We can’t proceed, we’re done, we spent almost a decade working on this and it’s a no go,’”…

Research bringing us closer to a cure for diabetes

November is National Diabetes Awareness Month

Research bringing us closer to a cure for diabetesAs part of the celebrations, we're revisiting five great stories showcasing the breadth of work being done at the University of Alberta in the journey towards a cure. For many of the 465 million people around the world living with diabetes, insulin is a lifeline. Since their bodies don’t produce enough of the hormone naturally…

Obesity, Type 2 diabetes leading risk factors for severe COVID-19

Link could hold the key to improving immune responses against COVID-19 and other viruses

Obesity, Type 2 diabetes leading risk factors for severe COVID-19A little-understood link between insulin resistance in cells and obesity could hold the key to improving immune responses against COVID-19 and other viruses, according to University of Alberta researcher Sue Tsai. “We hypothesize that insulin resistance in immune cells such as B cells is a major link between obesity and an impaired antiviral response, leading…

Edmonton-based partnership poised to close Canada’s drug supply gaps

Initiative could transform Alberta into a powerhouse in the development of life-saving therapies

Edmonton-based partnership poised to close Canada’s drug supply gapsA gap in homegrown drug manufacturing means that Canadians are at the mercy of the global supply chain when it comes to ensuring they have access to the drugs they need. Around 80 per cent of the raw ingredients for the world’s drugs are made in only two countries: China and India, according to a…

Biomanufacturing partnership boosts Canada’s vaccine capacity

New partnership ensures vaccine makers now have an option to manufacture their products domestically

Biomanufacturing partnership boosts Canada’s vaccine capacityVaccine makers, medical researchers and pharmaceutical companies now have a new full-service option to get their products manufactured in Canada, thanks to a partnership announced this week. The U of A’s Alberta Cell Therapy Manufacturing (ACTM) facility has signed a memorandum of understanding with The Ottawa Hospital’s Biotherapeutics Manufacturing Centre (BMC) and BioCanRx, a Canada-wide research network to develop…
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